Three C-3΄-N-sulfonyl and C-7-O-acyl paclitaxel analogues were synthesized from 10-deacetyl baccatin III (10-DAB) and their structures were confirmed by ¹H NMR, ¹³C NMR and HR-MS. Among them, the crystal structure of compound 9b was determined by single-crystal X-ray diffraction. Compound 9b crystallizes in monoclinic system, space group P2₁ with a = 12.395(4), b = 15.215(5), c = 14.905(5) Å, β = 105.559(4)° and Z = 2. In the structure, the introduction of the hydrophobic 3-fluorobenzoyl group at C(7) has little effect on the conformation of tetracyclic system. However, the conformation of the side-chain at C(13) in 9b is quite different from that of paclitaxel and docetaxel.