Unprecedent findings achieved by the research team represent an impressive breakthrough in structurally complex molecule determinations specifically by single-crystal X-ray diffraction analysis. Advances in determining the structures of alkyl-chain molecules directly promotes the precise design and synthesis of new drugs. The "supramolecular docking" strategy proposed by professor Huang and coworkers is expected to pave the way for pharmaceuticals, natural product chemistry and materials science. A possible direction of future research may be steered into various supramolecular docking systems and MOFs with larger cavities and adaptive recognition sites. As the continued evolution of MOF chemistry, current strategy will enable the determination of unknown structures that have been previously considered "undeterminable", and drive scientific innovations in molecular science.