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Folding codes in crystalline organic nanotubes: Toward synthetic cytoskeletons

Yujuan Zhuo, Xi Fan*, Zhangjing Zhang*

https://doi.org/10.1016/j.cjsc.2026.100986

ABSTRACT

Looking forward, a promising direction for this system may lie in engineering synthetic cytoskeleton-like scaffolds for protocells. Should dynamic linkages and noncovalent codes prove amenable to stimuli-responsive control, such nanotubes could potentially serve as reconfigurable frameworks within confined soft-matter environments (e.g., vesicles), which might one day enable oriented transport, spatial segregation, and the organization of reaction networks. In this sense, single-crystal polymer nanotubes offer not only critical structural insight but also a design logic that could inform the development of adaptive, life-mimetic architectures.



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